Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodríguez‐Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sónia Fonseca, Ana L. Carvalho, Simon Richard Carding, Michael M. Müller, Robert Charles Glen, David Vauzour, Simon McArthur
This study shows that TMAO enhances BBB integrity and protects against inflammation, while TMA impairs BBB function and cognitive resilience in mice.
Microbiome · Nov 26, 2021Peer-reviewedSystems Biology