Kristle Garcia

A map of RBP-miRNA regulatory connections for deciphering the mechanisms of transcriptome remodeling in cancer

The paper maps regulatory connections between RBPs and miRNAs in cancer, showing RBP-driven regulation contributes to miRNA activity heterogeneity and identifies DDX55 as a key regulator of miR-29-3p.

Systematic identification of chromatin organizers as tuners of intratumoral heterogeneity

The paper identifies RNF8 and MIS18A as chromatin organizers that modulate intratumoral heterogeneity in breast cancer, affecting therapeutic sensitivity and metastasis.

Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations

This study uses GENEVA to analyze drug response variations in cancer cells, revealing mitochondrial activation's role in KRAS inhibition and EMT as a resistance mechanism.

Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers

The paper systematically identifies and characterizes cancer-emergent oncRNAs across 32 tumor types, showing they act as blood-accessible molecular barcodes for cancer identity and prognosis.

Discovery of a tRNA-regulatory transcription factor that suppresses breast cancer metastasis

The paper identifies ZZEF1 as a tRNA-specific transcription factor that suppresses breast cancer metastasis by regulating tRNA-LysUUU expression and affecting codon-specific translation.

Learning chemical sensitivity reveals mechanisms of cellular response

The paper develops ChemProbe, a model that predicts cellular sensitivity to compounds using transcriptomes and chemical structures, and identifies genes driving ferroptosis.

Systematic Identification of Post-Transcriptional Regulatory Modules

The paper systematically identifies post-transcriptional regulatory modules by integrating multimodal data on RBP interactions and functions.

Generation of Schwann cell derived melanocytes from hPSCs identifies pro-metastatic factors in melanoma

The paper generates melanocytes from hPSCs through two distinct developmental trajectories and identifies T2-specific factors that promote melanoma metastasis.

RBMS1 suppresses colon cancer metastasis through targeted stabilization of its mRNA regulon

The paper identifies RBMS1 as a suppressor of colon cancer metastasis by stabilizing its mRNA targets, showing its clinical relevance in patient survival.