David J. Mooney

This paper introduces APC-ms, a platform that expands rare tumor-antigen-specific T cells from peripheral blood, achieving higher enrichment and functional properties compared to conventional methods.

This study shows that the viscoelastic properties of an alginate ECM regulate collagen fiber self-assembly through mechanical coupling.

This paper develops a microgel platform to enhance γδ T-cell expansion and function while preserving cytotoxicity and donor-specific responses.

This study shows that matrix viscoelasticity influences γδ T-cell phenotype and function, with slow-relaxing matrices enhancing cytotoxic programs and tumor control.

This study shows how mechanical forces and substrate properties enhance T-cell receptor proofreading by delaying decision-making and improving ligand discrimination.

This study shows that matrix viscoelasticity affects dendritic cell migration and immune responses by altering actomyosin dynamics and chromatin accessibility.

This study develops a feeder-free method to generate functional human dendritic cells from pluripotent stem cells, outperforming monocyte-derived dendritic cells in antigen presentation and T cell activation.

This study investigates the kinetics of de novo bone and bone marrow niche formation using a hybrid click cryogel system, showing that BMP-2 dose, immune status, and sex influence development rates and hematopoietic cell populations.

This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.

This study shows that ECM viscoelastic properties in bone fracture hematoma influence macrophage polarization, with high stress relaxation time promoting pro-inflammatory and low promoting anti-inflammatory responses.

This study evaluates inducible transgenic systems in human pluripotent stem cells and differentiated cells, identifying a small molecule-mediated splicing switch that enables tunable transgene expression without protein tags.

This paper presents an implantable material platform that contains engineered bacteria to autonomously deliver therapeutics in a mouse model of prosthetic joint infection.

This study shows that osmolality changes in bone marrow after fracture enhance mesenchymal stromal cell regeneration by altering ECM viscoelasticity and chromatin structure.

This study developed a DNA origami-based cancer vaccine that co-delivers antigen and CpG immune adjuvant with an optimal nanospacing for Th1 immune polarization.

This study shows that cyclic OKSM expression rejuvenates adult cardiomyocytes in mice with heart failure, improving systolic function without dedifferentiation.