Author

Xènia Serrat

University of TorontoORCID 0000-0001-7611-5400Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:C. elegans· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew G. FraseriD· 2 shared Julián CeróniD· 2 shared Carmen Martínez-FernándeziD· 1 shared Dmytro KukhtariD· 1 shared Hiroyuki HiranoiD· 1 shared Hiroyuki OsadaiD· 1 shared Igor ŠtagljariD· 1 shared Jamie D. SnideriD· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMolecular Biology

Andrew G. FraserORCID

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4 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 12, 2022

Identification of a novel family of benzimidazole species-selective Complex I inhibitors as potential anthelmintics

Taylor Davie, Xènia Serrat, Jamie D. Snider…·Andrew G. Fraser

The paper identifies a novel family of benzimidazole compounds that selectively inhibit Complex I in helminths, potentially serving as new anthelmintics.

DOI 10.1101/2022.09.12.507634

humanexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMar 24, 2021

Identification of enzymes that are required for Rhodoquinone-dependent metabolism as targets for new species-specific inhibitors

Margot J. Lautens, June H. Tan, Xènia Serrat…·Andrew G. Fraser

The paper identifies 4 helminth-specific enzyme targets for RQ-dependent metabolism that could be inhibited to develop new anthelmintics.

2 citations

humanstatistical model

𝕏 PostBluesky

GeneticsbioRxivPreprintAug 31, 2019

Splicing-related Retinitis Pigmentosa mutations mimicked in C. elegans allow the identification of disease modifiers and drug screens

Dmytro Kukhtar, Karinna Rubio-Peña, Xènia Serrat, Julián Cerón

The paper uses CRISPR in C. elegans to mimic human splicing factor mutations causing retinitis pigmentosa, identifies disease modifiers, and screens for drugs, finding harmful compounds.

DOI 10.1101/752956

C. elegansexperimental assay

𝕏 PostBluesky

GeneticsGeneticsPeer-reviewedJan 29, 2019

Efficient generation of endogenous fluorescent reporters by Nested CRISPR in Caenorhabditis elegans

Jeremy Vicencio, Carmen Martínez-Fernández, Xènia Serrat, Julián Cerón

The paper introduces a cloning-free Nested CRISPR method for efficiently generating endogenous fluorescent reporters in C. elegans with high editing efficiency.

61 citations

C. elegansexperimental assay

𝕏 PostBluesky