Hiroyuki Hirano

Population-scale chemical response revealed by a barcoded yeast collection

The paper develops a barcoded yeast collection to map genotype-phenotype relationships across genetic diversity, revealing genetic variants linked to chemical responses.

Identification of a novel family of benzimidazole species-selective Complex I inhibitors as potential anthelmintics

The paper identifies a novel family of benzimidazole compounds that selectively inhibit Complex I in helminths, potentially serving as new anthelmintics.

Improving prediction of compound function from chemical structure using chemical-genetic networks

The paper benchmarks structure descriptors and similarity coefficients using chemical-genetic interaction data to improve compound function prediction.

MOSAIC: a chemical-genetic interaction data repository and web resource for exploring chemical modes of action

The paper introduces MOSAIC, a database and web resource for chemical-genetic interaction data, enabling mode-of-action prediction and discovery of compound effects in yeast.

Functional Annotation of Chemical Libraries across Diverse Biological Processes

This study develops a yeast-based chemical-genetic screening system to annotate compound functionality across biological processes and identifies compounds with dual modes of action.