Teresa R. O’Meara

Defining the Candidozyma auris pan-genome and essentiality

This study defines the pan-genome of Candidozyma auris and identifies essential genes, revealing organism-specific biology and potential antifungal targets.

Candidozyma auris utilizes transferrin, but not heme-bound iron for in vivo virulence

This study shows Candidozyma auris uses transferrin-bound iron for growth and virulence, not heme, and identifies transferrin saturation as a host susceptibility factor.

Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi

This study shows that bacterial metabolites alter C. albicans cell wall composition, affecting antifungal resistance and immune recognition.

Standardizing RNA-seq Analysis of Fungal Pathogens Using BRC-Analytics and Agentic AI: A Candidozyma auris Case Study

The paper demonstrates a framework using BRC-Analytics and agentic AI to standardize RNA-seq analysis of fungal pathogens, achieving reproducible results across studies with differing annotations.

Convergent evolution on RBA1 regulates Candidozyma auris host adaptation

This study identifies loss-of-function mutations in RBA1 as a convergent adaptation in C. auris that enhances its ability to adhere, form biofilms, and cause infections.

Growth phase influences virulence in Candidozyma auris systemic infection models

This study compares the virulence of Candidozyma auris in different growth phases in mice, finding that log phase causes rapid mortality while stationary phase leads to extended survival.

Deep homology and design of proteasome chaperone proteins in Candida auris

The paper uses structural similarity to identify and design proteasome chaperone proteins in Candida auris, showing conservation of function despite sequence divergence.

Candida auris skin colonization is mediated by Als4112 and interactions with host extracellular matrix proteins

This study identifies Als4112 as critical for Candida auris skin colonization and explores collagen coatings to prevent adherence.

CryptoCEN: A Co-Expression Network for Cryptococcus neoformans reveals novel proteins involved in DNA damage repair

CryptoCEN, a co-expression network for Cryptococcus neoformans, identifies 13 novel DNA damage repair genes with 100% predictive accuracy.

Non-canonical activation of IRE1a during Candida albicans infection enhances macrophage fungicidal activity

This study shows that Candida albicans activates IRE1 in macrophages through non-canonical mechanisms, enhancing fungicidal activity by promoting phagolysosomal fusion.