Lenard M. Voortman

The paper presents a comprehensive segmentation strategy for cryoET data using convolutional neural networks, enabling efficient analysis of large datasets and improving particle picking and template matching.

This study correlates the structure of pathogenic and non-pathogenic PABPN1 protein aggregates with cellular function in differentiated muscle cells using multimodal imaging.

Ais provides a user-friendly, high-performance tool for cryo-electron tomography segmentation, accelerating particle picking and cellular architecture analysis.

The paper describes the design of a super-resolution fluorescence cryomicroscope for single molecule localization microscopy of cryosamples.

This paper outlines a workflow for SRcryoCLEM, demonstrating its application using Vimentin and showing how it enables targeted imaging of intracellular components in situ.

The paper investigates whether super-resolution fluorescence imaging before cryoEM affects resolution, finding no detrimental effect.

The paper investigates how support grid design in cryo-TEM affects fluorescence microscopy illumination and demonstrates improvements in super-resolution image quality through optimal grid selection.

The paper constructs a transcriptome atlas of human leg muscles, identifying molecular and cellular differences associated with muscle location and function.

This study assesses brain vascular structure and function in APP/PS1 mice with amyloid β plaques, finding no differences in cerebral blood volume or flow compared to wild-type controls.