Author

Ana Isabel Seixas

Universidade do PortoORCID 0000-0003-3237-777XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

Joana Paes de FariaiD· 2 shared João Bettencourt RelvasiD· 2 shared Andreia DiasiD· 1 shared Augusta MonteiroiD· 1 shared Bernd WollscheidiD· 1 shared Carolina LemosiD· 1 shared Chao ZhaoiD· 1 shared Cord BrakebuschiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersNeuroscience

Joana Paes de FariaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rac1 inhibition prevents axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy

Joana Magalhães, Vítor Pacheco Dias, Jessica Eira, Marina I. Oliveira da Silva, Guilherme Nóvoa, Margarida Martins, Hung‐Wei Kan, Andreia Dias, Estefânia Carvalho, Mariana Santos, Ana Isabel Seixas, Teresa Coelho, Ricardo Jorge Ferreira Taipa, Joana Paes de Faria, Carolina Lemos, , Márcia A. Liz

This study shows that Rac1 inhibition prevents cytoskeletal dysfunction in ATTRv-PN by rescuing axonal defects in mice and supporting its therapeutic potential in patients.

Cell Reports · Oct 1, 2025Peer-reviewedNeuroscience

Control of cortical cytoskeleton-membrane interaction by RhoA regulates peripheral nerve myelination

Ana Isabel Seixas, Miguel R. G. Morais, Cord Brakebusch, João Bettencourt Relvas

This study identifies RhoA's role in regulating Schwann cell myelination by controlling cytoskeleton-membrane interactions and biomechanical responses.

Progress in Neurobiology · Jun 12, 2023Peer-reviewedNeuroscience

The proteome of remyelination is different from that of developmental myelination

Joana Paes de Faria, Maria M. Azevedo, Damaris Bausch‐Fluck, Ana Isabel Seixas, Helena Sofia Domingues, Augusta Monteiro, Patrick G. A. Pedrioli, Eduarda Lopes, Rui Fernandes, Chao Zhao, Robin J.M. Franklin, Bernd Wollscheid, João Bettencourt Relvas, Laura Montani

The paper compares the proteome of remyelination and developmental myelination in mice, finding distinct protein compositions and identifying potential therapeutic targets.

bioRxiv · Mar 24, 2021 · PreprintNeuroscience