Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways
Yi Miao, Vikas Yadav, William R. Shadrick, Jiuyu Liu, Alexander R. Jenner, Connie B. Nichols, Clifford T. Gee, Martin Schäfer, Jennifer L. Tenor, John R. Perfect, Richard E. Lee Jr., Richard G. Brennan, E. Washington
This paper identifies 4456dh, a small molecule inhibitor of trehalose-6-phosphate synthase, which disrupts fungal thermal tolerance and virulence.
mBio · Aug 25, 2025Peer-reviewedMicrobiology