Author

Luke Slade

University of OxfordORCID 0000-0001-7660-7392Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 1 Organism:C. elegans· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:proteomics· 1

Frequent Co-Authors

Juan CabelloiD· 1 shared Krzysztof KuśiD· 1 shared Lidia VasiljevaiD· 1 shared Miloš R. FilipovićiD· 1 shared Peter SarkiesiD· 1 shared Yuanhang Jiang· 1 shared

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2026-2026 · peak 1/yr

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1 shared paperCell Biology

Juan CabelloORCID

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1 paper

Recent·Most cited

Cell BiologybioRxivPreprintApr 21, 2026

Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing

Luke Slade, Krzysztof Kuś, Yuanhang Jiang…·Lidia Vasiljeva

This study shows that reducing Integrator complex activity in adult C. elegans extends lifespan and healthspan by disrupting RNA processing and mitochondrial function.

DOI 10.64898/2026.04.18.719358

C. elegansbulk RNA-seq

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