Lidia Vasiljeva

Adulthood depletion of Integrator extends lifespan and healthspan via defective pre-mRNA processing

This study shows that reducing Integrator complex activity in adult C. elegans extends lifespan and healthspan by disrupting RNA processing and mitochondrial function.

The PP1 phosphatase complex coordinates pre-mRNA 3end processing and termination of RNA polymerase II transcription

This study shows that the PP1 phosphatase complex coordinates pre-mRNA 3' end processing and RNA polymerase II transcription termination through interactions with PNUTS and Symplekin.

DSIF factor Spt5 coordinates transcription, maturation and exoribonucleolysis of RNA polymerase II transcripts.

This study shows that Spt5 enhances Xrn2 activity to facilitate Pol II transcription termination and prevent non-coding transcript expression.

Conserved protein Seb1 that interacts with RNA polymerase II and RNA is a bona fide transcription elongation factor

This study shows that Seb1, a conserved CID-RRM factor, acts as a transcription elongation factor in fission yeast by modulating Pol II pausing.

RNA-binding protein Mub1 and the nuclear RNA exosome act to fine-tune environmental stress response

The paper identifies Mub1 as an RNA-binding protein that regulates exosome-dependent mRNA degradation, affecting stress response and gene expression.

System-wide analyses of the fission yeast poly(A)+ RNA interactome reveal insights into organisation and function of RNA-protein complexes

The paper uses poly(A)+ RNA-protein crosslinking data in fission yeast to analyze RNA-protein complexes and their functional organization.

Histone deacetylation promotes transcriptional silencing at facultative heterochromatin

The paper shows that HDAC-dependent histone deacetylation is critical for transcriptional silencing of facultative heterochromatin in fission yeast.