Author

Silvia Sposini

Centre National de la Recherche ScientifiqueORCID 0000-0001-7681-8376Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Aditi A. MaliiD· 1 shared Ana GoršeiD· 1 shared David PerraisiD· 1 shared Isabel D. AlvesiD· 1 shared Joyce Heuninck· 1 shared Mathias Lescuyer· 1 shared Pierre TrifilieffiD· 1 shared Rim BaccouchiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Aditi A. MaliORCID

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1 paper

Recent·Most cited

Cell BiologyNature CommunicationsPeer-reviewedMay 20, 2026

Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor internalization

Silvia Sposini, Rim Baccouch, Mathias Lescuyer…·Isabel D. Alves

This study shows that membrane poly-unsaturated fatty acids (PUFAs) impair dopamine D2 receptor (D2R) endocytosis without affecting other GPCRs or clathrin-mediated endocytosis.

DOI 10.1038/s41467-026-73057-5

humanproteomics

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