Pierre Trifilieff

This study shows that dietary changes in n-3 LC-PUFA supply alter brain phospholipid composition but not ganglioside composition in mice.

This study shows that membrane poly-unsaturated fatty acids (PUFAs) impair dopamine D2 receptor (D2R) endocytosis without affecting other GPCRs or clathrin-mediated endocytosis.

This study shows that developmental vitamin A deficiency causes sex-specific changes in reward processing in adult mice by altering mesolimbic dopamine transmission.

This study shows that an obesogenic diet impairs memory consolidation in mice via the hippocampal endocannabinoid system and mTOR pathway, which can be reversed by CB1R blockade or mTOR inhibition.

This study shows that dopamine signaling in the medial prefrontal cortex encodes action value during reversal learning through D1/NMDA and D2/NMDA receptor heteromers.

This study investigates the role of NAc D1 and D2 neurons in balancing feeding and exercise-mediated energy expenditure in mice, finding that manipulating these neurons affects energy balance and weight.

This study shows that an obesogenic diet during adolescence impairs specific memory types via overactivation of hippocampal pathways, and targeting these pathways can reverse deficits.

This study identifies ANKK1's role in striatal DR2-expressing neurons, linking it to reward, metabolism, and behaviors associated with the A1 allele of TaqIA.

The paper identifies hub synapses in the mouse striatum formed by dopaminergic inputs that connect with glutamatergic, GABAergic, and cholinergic synapses, revealing a new framework for studying neuromodulation.

The paper shows disrupting D2-NMDA receptor heteromerization blocks cocaine's rewarding effects without affecting natural reward processing in mice and humans.

The paper demonstrates D2R-A2AR proximity in human ventral striatum using PLA and a Bayesian classifier, supporting their potential formation of heteromers.