Saumya Gupta

The paper identifies multiple independent GPRC6A gene loss events across vertebrates, challenging the notion of its universal functionality and suggesting lineage-specific adaptations.

The paper introduces a spike-in method to improve allele-specific expression analysis by reducing technical noise and cost.

The paper investigates the persistence of allelic expression patterns in murine hematopoietic stem cells and their differentiated B-cell clones, finding that most allele-specific transcriptional states are established de novo during differentiation.

The paper identifies DNA methylation as a key mechanism for maintaining monoallelic expression on autosomes and reveals its tunable control of allele-specific expression.

The paper assesses allelic imbalance variability in RNA sequencing and finds technical replicates show up to 7-fold higher variation than expected, which can be mitigated to improve differential analysis.

The paper uses network theory on longitudinal gene expression data to identify key genes affecting sporulation efficiency in yeast.

The paper investigates the functional consequences of a rare TAO3 variant in yeast, revealing its meiotic role and identifying new regulators of sporulation efficiency.