Author

Michael D. Koob

University of MinnesotaORCID 0000-0001-7738-8232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Kellie A. Benzow· 3 shared Harry T. OrriD· 2 shared Kul B. Karanjeet· 2 shared Marija CvetanovićiD· 2 shared Adem SelimoviciD· 1 shared Alana R. Rodney· 1 shared Alyssa SolesiD· 1 shared Angela Minnella· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersNeuroscience

Kellie A. Benzow

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Mutant ATXN1 impacts human and mouse microglia and contributes to cognitive, mood, and motor deficits in SCA1 mice

Adem Selimovic, Gourango Talukdar, Gavin J. Fuchs, Vamika Sharma, Khadija N Abbas, Sriyan C Reddy, Eshaan Parnerkar, Ian M. Brooks, Ying Zhang, Michael D. Koob, Yasushi Nakagawa, Harry T. Orr, Marija Cvetanović

This study shows that mutant ATXN1 affects microglia in human and mouse models, leading to cognitive, mood, and motor deficits in SCA1 mice, which are ameliorated by reducing mutant ATXN1 in microglia.

bioRxiv · Feb 17, 2026 · PreprintNeuroscience

MAPT Splicing Modulators as a Therapeutic Strategy for Tauopathies

M. Catarina Silva, Hannah Lindmeier, Paolo Pigini, Jennifer Laughlin, Yong Yu, Christie Morrill, Michael A. Arnold, Scott J. Barraza, Khalil Saadipour, Monal Dieterich, Angela Minnella, Kausiki Datta, Nanjing Zhang, Jana Narasimhan, Christopher R. Trotta, , Elisabetta Morini

Discovery of SMCs that correct MAPT splicing, reduce 4R tau, and rescue pathology in patient-derived neuronal and in vivo models of 4R tauopathies.

bioRxiv · May 6, 2025 · PreprintNeuroscience

A common Alu element insertion in the 3'UTR of TMEM106B is associated with an increased risk of dementia

Alana R. Rodney, Kul B. Karanjeet, Kellie A. Benzow, Michael D. Koob

The paper identifies an AluYb8 insertion in the 3'UTR of TMEM106B associated with increased dementia risk and shows it is shared across risk alleles.

bioRxiv · Sep 7, 2023 · PreprintGenetics

Delineating regional vulnerability in the neurodegenerative disease SCA1 using a conditional mutant ATXN1 mouse

Lisa A. Duvick, William M. Southern, Kellie A. Benzow, Zoe N. Burch, Hillary P. Handler, Jason S. Mitchell, Hannah Kuivinen, Udaya Keerthy Gadiparthi, Praseuth Yang, Alyssa Soles, Carrie A. Sheeler, Orion Rainwater, Shannah Serres, Erin B. Lind, Tessa Nichols‐Meade, , Harry T. Orr

This study identifies brain regions and cell types contributing to SCA1 disease using conditional knockout mice, showing that targeting multiple areas and muscle is necessary for effective therapy.

bioRxiv · Feb 8, 2023 · PreprintNeuroscience