Author

Noe B. Mercado

Brown UniversityORCID 0000-0001-7769-7326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Sean Edward LawleriD· 3 shared Charles H. CookiD· 2 shared Eleni PanagiotiiD· 2 shared Philippa C. Vaughn-BeaucaireiD· 2 shared William M. Hawkins· 2 shared Alexander S. BrodskyiD· 1 shared Andrea Schmidt· 1 shared Andrea SchmidtiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersCancer Biology

Sean Edward LawlerORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintAug 21, 2026

Preclinical evaluation of Brincidofovir in glioblastoma demonstrates improved long term-survival and cytomegalovirus-dependent and independent effects

Noe B. Mercado, Philippa C. Vaughn-Beaucaire, William M. Hawkins…·Sean Edward Lawler

This study evaluates Brincidofovir's effects on glioblastoma, showing improved survival and both CMV-dependent and independent antitumor activity.

DOI 10.64898/2026.08.20.746020

mousebulk RNA-seq

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ImmunologybioRxivPreprintJan 20, 2026

MAPKAP Kinase 2 Orchestrates Memory T Cell Inflation in Cytomegalovirus Infection

Eleni Panagioti, Xueyang Yu, Yi Wen Kong…·Charles H. Cook

This study shows that MK2 regulates CD8 T cell inflation during CMV infection by affecting their expansion and differentiation.

DOI 10.64898/2026.01.16.699974

mouseflow cytometry

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Cancer BiologyScience AdvancesPeer-reviewedFeb 26, 2025

Modulation of blood-tumor barrier transcriptional programs improves intra-tumoral drug delivery and potentiates chemotherapy in GBM

Jorge L. Jimenez-Macias, Philippa C. Vaughn-Beaucaire, Ayush Bharati…·Sean Edward Lawler

This study identifies a 12-gene BTB signature, shows CDH5 as a core component, and demonstrates that BIA disrupts the BTB to enhance chemotherapy delivery and efficacy in GBM.

24 citationstop 1%

humanspatial transcriptomics

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