Mathew McLaren

Cryo-EM reveals multiple mechanisms of ribosome inhibition by doxycycline

This study uses cryo-EM to show doxycycline binds to the ribosome exit tunnel in C. burnetii and E. coli, revealing new mechanisms of ribosome inhibition.

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This study uses cryo-EM to determine the near-atomic structure of the archaeal virus HFTV1, revealing insights into its assembly, infection mechanisms, and host-virus interactions.

New clues about ribosome hibernation and activation in microsporidia revealed by cryo electron tomography

The paper uses cryo-electron tomography to reveal structural insights into ribosome hibernation in microsporidian spores, showing ribosome dimers arranged in ordered arrays around the polar tube.

In situ structure of a dimeric hibernating ribosome from a eukaryotic intracellular pathogen

The paper investigates hibernating ribosomes in the microsporidian parasite Spraguea lophii using cryoET and cryoEM, revealing a unique dimeric structure and the role of MDF1 in translation inhibition.