Molecular BiologybioRxivPreprint
Mutant forms of DDX3X with diminished catalysis form hollow condensates that exhibit sex-specific regulation
Michael C. Owens, Hui Shen, Amber M. Yanas…·Kathy Fange Liu
This study shows that specific DDX3X mutants form hollow condensates, impairing catalytic activity and interacting differently with WT DDX3X and DDX3Y, which may explain sex-specific disease biases.
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