Him Shweta

This study identifies nanometer-scale RNA-protein clusters (RPCs) formed by eIF4A with cofactors eIF4B and eIF4G, showing their role in enhancing helicase activity through multivalent RNA interactions.

The paper shows DDX3X and DDX3Y form RNA-protein clusters that enhance their enzymatic activity and may promote liquid-liquid phase separation under stress.

This study shows that specific DDX3X mutants form hollow condensates, impairing catalytic activity and interacting differently with WT DDX3X and DDX3Y, which may explain sex-specific disease biases.