Author

Michael C. Owens

University of PennsylvaniaORCID 0000-0001-9425-106XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Amber M. YanasiD· 2 shared Him ShwetaiD· 2 shared Kathy Fange LiuiD· 2 shared Yale E. GoldmaniD· 2 shared Ellen Lavorando· 1 shared Hsin‐Yao TangiD· 1 shared Hui SheniD· 1 shared Maria Saraí Mendoza-FigueroaiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersBiophysics

Amber M. YanasORCID

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2 papers

Recent·Most cited

BiophysicsCurrent BiologyPeer-reviewedNov 25, 2024

DDX3X and DDX3Y constitutively form nano-sized RNA-protein clusters that foster enzymatic activity

Amber M. Yanas, Him Shweta, Michael C. Owens…·Yale E. Goldman

The paper shows DDX3X and DDX3Y form RNA-protein clusters that enhance their enzymatic activity and may promote liquid-liquid phase separation under stress.

25 citations

humanproteomics

𝕏 PostBluesky

Molecular BiologybioRxivPreprintMar 19, 2023

Mutant forms of DDX3X with diminished catalysis form hollow condensates that exhibit sex-specific regulation

Michael C. Owens, Hui Shen, Amber M. Yanas…·Kathy Fange Liu

This study shows that specific DDX3X mutants form hollow condensates, impairing catalytic activity and interacting differently with WT DDX3X and DDX3Y, which may explain sex-specific disease biases.

2 citations

humanproteomics

𝕏 PostBluesky