Dmitri Ivanovich Kotov

This study identifies Mtb's enzymatic inactivation of host oxysterols as a mechanism to disrupt macrophage cholesterol homeostasis and generate treatment-responsive metabolic signatures in TB.

This study establishes a mouse model to investigate adaptive immunity to oral Shigella infection and identifies CD4+ T cells as critical for cross-serotype protection through IFN-gamma and IgA production.

The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.

This study shows that Mycobacterium tuberculosis is resistant to innate immune clearance even under conditions that enhance innate immunity.

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.