Stefan A. Fattinger

This study establishes a mouse model to investigate adaptive immunity to oral Shigella infection and identifies CD4+ T cells as critical for cross-serotype protection through IFN-gamma and IgA production.

The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.