Marian R. Fairgrieve

Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility

The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.

Diverse infection models demonstrate robust resistance of Mycobacterium tuberculosis to innate immunity

This study shows that Mycobacterium tuberculosis is resistant to innate immune clearance even under conditions that enhance innate immunity.