Author

Roberto A. Chavez

Howard Hughes Medical Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Dmitri Ivanovich KotoviD· 4 shared Russell E. VanceiD· 4 shared Stefan A. FattingeriD· 3 shared Angus Y. Lee· 2 shared Ella C. BrydoniD· 2 shared Harmandeep S Dhaliwal· 2 shared Kristen C. WittiD· 2 shared Marian R. FairgrieveiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersImmunology

Dmitri Ivanovich KotovORCID

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4 papers

Recent·Most cited

Mechanisms of mucosal immunity to oral Shigella infection in a physiological mouse model

Janet Peace Babirye, Emma F. Lackner, Sudyut Yuvaraj, Roberto A. Chavez, Charlotte A. Nichols, Kevin Eislmayr, Stefan A. Fattinger, Dmitri Ivanovich Kotov, Cammie F. Lesser, Russell E. Vance

This study establishes a mouse model to investigate adaptive immunity to oral Shigella infection and identifies CD4+ T cells as critical for cross-serotype protection through IFN-gamma and IgA production.

bioRxiv · Sep 14, 2026 · PreprintImmunology

Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility

Stefan A. Fattinger, Parisi Bianca, Roberto A. Chavez, Marian R. Fairgrieve, Ophelia V. Lee, Kristen C. Witt, Jesse J Rodriguez, Elizabeth A Turcotte, Ella C. Brydon, Harmandeep S Dhaliwal, Angus Y. Lee, Dmitri Ivanovich Kotov, Russell E. Vance

The paper shows that sustained type I IFN signaling in infected macrophages impairs IFNγ responses, leading to tuberculosis susceptibility.

Cell Host & Microbe · Aug 14, 2026Peer-reviewedImmunology

Diverse infection models demonstrate robust resistance of Mycobacterium tuberculosis to innate immunity

Marian R. Fairgrieve, Ella C. Brydon, Roberto A. Chavez, Dmitri Ivanovich Kotov, Russell E. Vance

This study shows that Mycobacterium tuberculosis is resistant to innate immune clearance even under conditions that enhance innate immunity.

bioRxiv · Nov 20, 2025 · PreprintImmunology

The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

Kristen C. Witt, Adam Dziulko, Joohyun An, Filip Pekovic, Arthur Xiuyuan Cheng, Grace Y. Liu, Ophelia V. Lee, David J. Turner, A. C. Lari, Moritz M. Gaidt, Roberto A. Chavez, Stefan A. Fattinger, Preethy Abraham, Harmandeep S Dhaliwal, Angus Y. Lee, , Russell E. Vance

This study identifies SP140's role in regulating IFN-β mRNA stability through RESIST, revealing a dual antiviral and interferon regulatory function.

Nature · Jun 11, 2025Peer-reviewedImmunology