This paper constructs a single-cell atlas of uterine carcinosarcoma across diverse ancestries, revealing cancer cell plasticity and stromal-immune remodeling in primary and metastatic tumors.

bioRxiv · Jul 10, 2026 · PreprintCancer Biology

A High-Fidelity and Ancestrally Inclusive Patient-Derived Organoid Platform Resolves Cancer Cell Plasticity in Uterine Carcinosarcoma

Santhilal Subhash, Marie‐Therese Bammert, Brian Yueh, Kadir Ozler, Timothy H. Chu, Melissa Kramer, Pascal Belleau, Astrid Deschênes, Onur Eskiocak, Vyom Shah, Charlie Chung, Ali Oku, Mali Barbi, Aybuke Alici-Garipcan, Megan Gorman, , Semir Beyaz

This paper develops an ancestrally inclusive patient-derived organoid platform for UCS that captures cancer cell plasticity and identifies therapeutic vulnerabilities.

bioRxiv · Jul 6, 2026 · PreprintCancer Biology

Microbial induction of MHC-II expression in colon cancer cells overcomes immunotherapy resistance and limits metastasis

Charlie Chung, Elif Ozcelik, J Zhang, Zeli Shen, Onur Eskiocak, Yihan Qin, Jill Habel, Kadir Ozler, Santhilal Subhash, Zakaria Aminzada, Gagan Dev, Libia A. Garcia, Scott K. Lyons, Timothy Wesley Hand, David E. Rivadeneira, , Semir Beyaz

This study shows that a microbiome-dependent mechanism increases MHC-II expression in colon cancer cells, enhancing immunotherapy response and limiting metastasis.

bioRxiv · Jul 4, 2026 · PreprintImmunology

Diverse high-fat diets drive multi-omic reprogramming that persists after dietary reversal

Andrew G. Van Camp, Jiwoon Park, Elif Ozcelik, Onur Eskiocak, Kadir Ozler, Katie Papciak, Santhilal Subhash, Hanan Alwaseem, Ilgin Ergin, Charlie Chung, Vyom Shah, Brian Yueh, Aybuke Alici-Garipcan, Miriam R. Fein, Ceyda Durmaz, , Sneak Peek Administrator

The paper investigates how different high-fat diets affect host and microbiome multi-omic states over time and shows that some changes persist even after returning to a control diet.

bioRxiv · Apr 23, 2026 · PreprintSystems Biology