Geneviève Almouzni

The paper investigates how different routes to whole-genome duplication (WGD) affect nuclear stability, finding that mitotic slippage uniquely causes nuclear instability.

The paper quantifies 3D cellular organization in two Xenopus species to show how tissue architecture converges despite differences in size and cell number.

This study identifies the nuclear localization and interactome of TBEV NS5 protein, revealing its role in modulating viral replication through interactions with nuclear factors.

The paper investigates how nucleosome positioning, DNA structure, and transcription factor binding contribute to the function of ultra-conserved developmental enhancers.

The paper describes an optimized spatial transcriptomics workflow for Xenopus embryos, enabling high-resolution gene expression mapping across developmental stages.

The paper shows HIRA regulates early replication initiation zones independently of chromatin accessibility, histone marks, and 3D compartment organisation.

This study shows that CENP-A, a centromeric histone variant, epigenetically regulates epithelial-mesenchymal plasticity and heterogeneity in human cells through non-centromeric mechanisms.

The paper shows H3.3 deposition counteracts H3.1 enrichment at chromocenters in ESCs, affecting heterochromatin stability and cell survival.

This study shows that HIRA-dependent histone H3.3 deposition maintains 3D genome compartmentalisation in active chromatin, independent of histone PTMs.

The paper shows ASF1 regulates replicative histone RNA metabolism by affecting RNA processing and stability, ensuring proper histone dosage during DNA replication.

The paper shows that H3.3S31 phosphorylation is critical for development at gastrulation in Xenopus, regardless of the deposition pathway.