Jerzy O. Szablowski

This paper introduces a cell-based sensor called LUNAR that detects extracellular double-stranded DNA with nanomolar sensitivity in mammalian cells.

This paper introduces a platform called INTACT that non-invasively monitors specific mRNA levels in vivo by using synthetic serum markers and RNA-based sensors.

This study introduces RMAs, synthetic serum markers that enable noninvasive monitoring of gene expression in primate brains via blood tests over three months.

This study uses synthetic serum markers (RMAs) to monitor retinal gene expression and cell survival through blood tests, showing high sensitivity and non-destructiveness.

This study evaluates FUS-BRBO for retinal gene delivery, showing AAV.FUS.3 achieves 2.1-fold and 19.5-fold higher transduction than AAV9 in insonated and uninsonated retinas, respectively.

This paper introduces erasable serum markers (ESMs) to improve the sensitivity and temporal resolution of brain gene expression monitoring through blood tests.

This paper models synthetic serum markers to determine the theoretical limits of temporal resolution and precision in monitoring gene expression through blood draws.

This study demonstrates that AAV9.retro can safely and efficiently deliver genes to neuronal projections noninvasively using FUS-BBBO, offering improved specificity compared to invasive methods.

This study uses acoustically targeted chemogenetics to non-invasively increase seizure threshold in mice by inhibiting hippocampal pyramidal neurons.

This paper introduces a noninvasive method to monitor brain gene expression using engineered reporters called RMAs, which detect neuronal activity through blood measurements.

This paper introduces a noninvasive method to control specific neural circuits using acoustically targeted chemogenetics, demonstrating its ability to modulate hippocampal neurons and affect memory formation in mice.