Sangsin Lee

Cell-Based Sensor for Extracellular DNA

This paper introduces a cell-based sensor called LUNAR that detects extracellular double-stranded DNA with nanomolar sensitivity in mammalian cells.

Monitoring in vivo transcription with synthetic serum markers

This paper introduces a platform called INTACT that non-invasively monitors specific mRNA levels in vivo by using synthetic serum markers and RNA-based sensors.

Monitoring Gene Expression in Retina with Synthetic Serum Markers

This study uses synthetic serum markers (RMAs) to monitor retinal gene expression and cell survival through blood tests, showing high sensitivity and non-destructiveness.

Erasable Synthetic Serum Markers

This paper introduces erasable serum markers (ESMs) to improve the sensitivity and temporal resolution of brain gene expression monitoring through blood tests.

Noninvasive Control of Seizure Threshold with Acoustically Targeted Chemogenetics

This study uses acoustically targeted chemogenetics to non-invasively increase seizure threshold in mice by inhibiting hippocampal pyramidal neurons.

Engineered Serum Markers for Noninvasive Monitoring of Gene Expression in the Brain

This paper introduces a noninvasive method to monitor brain gene expression using engineered reporters called RMAs, which detect neuronal activity through blood measurements.