Erin Piazza

Sub-cellular Imaging of the Entire Protein-Coding Human Transcriptome (18933-plex) on FFPE Tissue Using Spatial Molecular Imaging

This paper introduces a high-plex spatial molecular imaging technique capable of sub-cellular transcriptome analysis of FFPE tissues, achieving whole transcriptome coverage with high resolution and minimal dissociation bias.

High-plex Multiomic Analysis in FFPE at Subcellular Level by Spatial Molecular Imaging

An automated in-situ imaging platform reads 980 RNAs and 108 proteins in FFPE tissue at subcellular resolution, with 0.0092 false calls per cell; 800,000-plus cells released publicly.

Spatially resolved whole transcriptome profiling in human and mouse tissue using Digital Spatial Profiling

Multiplexed in situ hybridization pools against every protein-coding gene let Digital Spatial Profiling read whole transcriptomes from regions of ~10-500 cells in human and mouse tissue.

A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease

The paper introduces a NanoString nCounter Mouse AD panel to assess LOAD mouse models by correlating gene expression with human AD modules, showing strong correlation with RNA-Seq data.

Advances in mixed cell deconvolution enable quantification of cell types in spatially-resolved gene expression data

SpatialDecon quantifies cell populations in spatially-resolved gene expression data, showing spatially heterogeneous immune responses in lung tumors.