Kate E. Foley

The paper assesses neurovascular uncoupling in APOE variants, finding APOEε4/ε4 shows Type-1 uncoupling and APOEε3/ε4 shows Type-2 uncoupling in aging mice.

This study shows that APOEϵ4 genotype interacts with exercise to influence systemic and cerebral risk factors for dementia in mice, with sex-specific effects on metabolism, brain function, and aging.

This study identifies unique gene signatures in the cortex of young mice with APOEε3/ε4 and APOEε4/ε4 genotypes, showing distinct transcriptomic and functional differences.

This paper creates a mouse model expressing human CR1 and CR2 variants to study their role in disease.

This study shows that running promotes cerebrovascular remodeling in young mice but not aged mice, suggesting exercise may be more effective for dementia prevention when started early.