Brandon W. Simone

This paper introduces DdCBEs with modified TALE proteins that remove the 5-T constraint, enabling efficient and specific mitochondrial base editing at previously inaccessible sites.

This paper introduces a Donorguide technology that improves HDR efficiency and precision by fusing an ssDNA template to tracrRNA, showing enhanced results in vitro and in vivo.

This paper characterizes ErCas12a, a new CRISPR/Cas system, showing it enables efficient DNA repair and gene integration in zebrafish and human cells.