Chih-Chun Lin

This study shows that a yeast prion modulates host physiology in Drosophila by affecting cold tolerance and locomotion through gut-brain signaling pathways.

This study uses optogenetic control to manipulate gut bacterial metabolism in C. elegans and shows that increased colanic acid production extends lifespan.

The paper identifies specific bacterial metabolites affecting C. elegans physiology and develops an RNA interference strain to study genotype-phenotype interactions without microbial confounding.