Author

Xiaoke Xu

Broad InstituteORCID 0000-0002-4033-1774Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Organism:human· 1

Frequent Co-Authors

Howard S. FoxiD· 2 shared Katy M. EmanueliD· 2 shared Meng NiuiD· 2 shared Amy Grayson· 1 shared Andrew J. TreaseiD· 1 shared Benjamin G. Lamberty· 1 shared Bingqiu XiuiD· 1 shared Chuqian LiangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

Howard S. FoxORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Circadian misalignment underlies immune escape in breast cancer

Chuqian Liang, Zunpeng Liu, Xiaoke Xu, Zhen Xu, Qi Zhang, Tao Zhang, Riley J. Mangan, Bingqiu Xiu, Gongwei Wu, Tara K. Akhshi, Zachary M. Sandusky, G. Kenneth Gray, Na Zhang, Genevra M. Kuziel, Nicole A. Traphagen, , Myles Brown

The paper identifies circadian misalignment between cancer and immune cells in breast tumors as a mechanism of immune evasion and therapeutic resistance.

bioRxiv · May 29, 2026 · PreprintCancer Biology

Cocaine Acts Through Sigma-1 to Enhance HIV Infection of Microglia

Oluwatofunmi Oteju, Xiaoke Xu, Taylor Kist, Katy M. Emanuel, Lexi Sheldon, Marzieh Daniali, Meng Niu, Howard S. Fox, Peter J. Gaskill

This study shows cocaine enhances HIV infection of microglia via sigma-1 activation, which modulates the UPR to boost viral replication and immune evasion.

bioRxiv · Aug 6, 2025 · PreprintImmunology

Microglia and macrophages alterations in the CNS during acute SIV infection: a single-cell analysis in rhesus macaques

Xiaoke Xu, Meng Niu, Benjamin G. Lamberty, Katy M. Emanuel, Shawn Ramachandran, Andrew J. Trease, Mehnaz Tabassum, Jeffrey D. Lifson, Howard S. Fox

This study uses single-cell RNA sequencing to analyze microglia and macrophages in rhesus macaques during acute SIV infection, revealing changes in cell clusters and gene expression linked to inflammation and neurodegeneration.

PLoS Pathogens · Sep 16, 2024Peer-reviewedMicrobiology