Cancer BiologyCancer Research CommunicationsPeer-reviewed
Age-related increases in fibroblasts-secreted IGFBP2 increase melanoma cell invasion and lipid synthesis.
Gretchen Marie Alicea, Payal Patel, Marie Elena Portuallo…·Ashani T. Weeraratna
This study shows that aged fibroblasts secrete more IGFBP2, which promotes melanoma cell invasion and lipid synthesis, and that neutralizing IGFBP2 reduces tumor growth and metastasis.
14 citations