Nutrient starvation activates ECM remodeling gene enhancers associated with inflammatory bowel disease risk in fibroblasts
Stefano Secchia, Vera Beilinson, Xiaoting Chen, Zi F. Yang, Joseph A. Wayman, Jasbir Dhaliwal, Ingrid Jurickova, Elizabeth B. Angerman, Lee A. Denson, Emily R. Miraldi, Matthew T. Weirauch, Kohta Ikegami
The paper shows nutrient starvation activates ECM remodeling gene enhancers linked to IBD risk in fibroblasts, suggesting a mechanism for pathological fibroblast activation in IBD.
bioRxiv · Sep 6, 2024 · PreprintGenomics