Lokesh Sharma

This study identifies VEGF-D as a key factor in maintaining lung vascular integrity during acute lung injury using single-cell RNA sequencing and functional assays.

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

This study uses scRNA-seq and scATAC-seq to show chronic cigarette smoke exposure enhances inflammatory and survival pathways in lung epithelial responses to influenza and hyperoxia.

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

This study identifies chitin oligomers as the smallest immunologically active motif and TLR2 as the primary receptor for chitin, showing size-dependent signaling and therapeutic potential.