Author

Riham Smoom

Hebrew University of JerusalemORCID 0000-0002-6769-9798Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:genome assembly· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Klaus H. KaestneriD· 3 shared Yehuda TzfatiiD· 3 shared Catherine Lee May· 2 shared Dan Lichtental· 2 shared Emmanuel SkordalakesiD· 2 shared Melissa M. Rowe· 2 shared Vivian OrtiziD· 2 shared Ashleigh R. Morgan· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenetics

Klaus H. KaestnerORCID

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3 papers

Recent·Most cited

Human length telomeres restrict the regenerative potential of hematopoietic stem cells in mice

Melissa M. Rowe, Joanna M. Tober, Vivian Ortiz, Riham Smoom, Yehuda Tzfati, Nancy A. Speck, Klaus H. Kaestner

The paper shows that human-length telomeres in mice restrict hematopoietic stem cell regenerative potential under stress conditions.

Journal of Biological Chemistry · Jul 24, 2026Peer-reviewedGenetics

Separation of telomere protection from length regulation by two different point mutations at amino acid 492 of RTEL1

Riham Smoom, Catherine Lee May, Dan Lichtental, Kamil Bar-Ness, Reina Rangel, Johad Khoury, Daphna Nachmani, Dana Avrahami, Farida Ahangari, Emmanuel Skordalakes, Naftali Kaminski, Klaus H. Kaestner, Yehuda Tzfati

This study introduces two RTEL1 mouse models with distinct mutations at amino acid 492, showing that M492K affects telomere length while M492I impairs telomere protection, leading to different disease phenotypes.

Nucleic Acids Research · May 29, 2025Peer-reviewedGenetics

Telomouse - a mouse model with human-length telomeres generated by a single amino acid change in RTEL1

Riham Smoom, Catherine Lee May, Vivian Ortiz, Mark Tigue, Hannah M. Kolev, Melissa M. Rowe, Yitzhak Reizel, Ashleigh R. Morgan, Nachshon Egyes, Dan Lichtental, Emmanuel Skordalakes, Klaus H. Kaestner, Yehuda Tzfati

This paper introduces a mouse model with human-length telomeres by modifying RTEL1 and shows its impact on regenerative capacity.

Nature Communications · Oct 23, 2023Peer-reviewedGenetics