Author

Searlait Thom

Newcastle University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:differential expression· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Daniel ErskineiD· 2 shared Tiago F. OuteiroiD· 2 shared Ana ChegãoiD· 1 shared Angela PyleiD· 1 shared Annabelle E. Hartanto· 1 shared Annekatrin König· 1 shared Clara Bosbach· 1 shared Claudia SteinemiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Daniel ErskineORCID

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2 papers

Recent·Most cited

Glycation of alpha-synuclein enhances aggregation and neuroinflammatory responses

Eftychia Vasili, Annekatrin König, Mohammed Al‐Azzani, Clara Bosbach, Luisa Maria Gatzemeier, Searlait Thom, Ana Chegão, Hugo Vicente Miranda, Claudia Steinem, Daniel Erskine, Tiago F. Outeiro

This study shows that glycation of alpha-synuclein increases its aggregation and neuroinflammatory responses, linking type 2 diabetes and Parkinson's disease.

npj Parkinson s Disease · Oct 23, 2025Peer-reviewedNeuroscience

Seed-competent alpha-synuclein pathology in metachromatic leukodystrophy: the expanding spectrum of alpha-synucleinopathy in sphingolipidoses

Simona S. Ghanem, Jade I. Hawksworth, Searlait Thom, Annabelle E. Hartanto, Joseph O’Neill, Janarthanan Ponraj, Said A Mansour, Johannes Attems, Angela Pyle, Lauren R. Johnson, Jack P. Baines, Robert William Taylor, Tiago F. Outeiro, Omar M. A. El‐Agnaf, Daniel Erskine

This study examines alpha-synuclein pathology in metachromatic leukodystrophy (MLD) brain tissue, finding seed-competent alpha-synuclein conformers in juvenile-onset cases, similar to Lewy body diseases.

bioRxiv · Aug 9, 2024 · PreprintNeuroscience