Pedro Carvalho

The paper identifies how mistargeted mitochondrial proteins are rerouted to the ER and cleared via ERAD, with MARCHF6 playing a central role in maintaining proteostasis during mitochondrial dysfunction.

This study shows seipin undergoes conformational changes at the ER-LD interface, enabling lipid droplet growth and regulated lipid storage.

The paper shows that chronic hyperosmotic stress in budding yeast leads to lipid droplet accumulation and membrane remodelling, which are essential for cell fitness.

The paper investigates the molecular architecture of the yeast seipin complex and its interaction with regulatory proteins under different metabolic conditions.

The paper identifies CTDNEP1-NEP1R1 as the R-SMAD phosphatase and shows how its complex with MAN1 inactivates TGF-β signaling by dephosphorylating R-SMADs in the nucleus.

This study identifies Pex30's role in maintaining ER lipid homeostasis through membrane contact sites with peroxisomes and vacuoles in budding yeast.