Kazuya Toriumi

High Sucrose Diets Contribute to Brain Angiopathy with Impaired Glucose Uptake, and Psychosis-related Higher Brain Dysfunctions in Mice

This study shows that high-sucrose diets in Glo1-deficient mice cause brain angiopathy, impaired glucose uptake, and psychosis-related behaviors, with aspirin offering protection.

Cell-type and cytosine context-specific evolution of DNA methylation in the human brain

The paper investigates DNA methylation evolution in human brain cells, showing reduced CG methylation and increased CH methylation, linked to schizophrenia risk.

Impairment of methylglyoxal detoxification systems causes mitochondrial dysfunction and schizophrenia-like behavioral deficits

This study shows that impaired methylglyoxal detoxification in mice leads to mitochondrial dysfunction and schizophrenia-like behaviors.

Cell-type specific epigenetic links to schizophrenia risk in brain

The paper analyzes cell-type specific DNA methylation and transcriptomes in schizophrenia brains, finding reduced epigenetic distinction between cell types in schizophrenia.