Jinrong Huang

The paper integrates single-cell and single-nucleus RNA sequencing data to identify biomarkers associated with NAFLD severity and their intercellular signaling roles.

The paper identifies QSOX1 and IL1RAP as biomarkers for NAFLD severity using gene clustering and validates their plasma ratio as a non-invasive diagnostic tool.

The paper analyzes single-cell RNA-seq data from human embryos to compare gene expression between males and females, identifying differences in sex chromosome activation and dosage compensation during early development.

This study demonstrates CRISPR/Cas9 can generate extrachromosomal circular DNA and ring chromosomes in human cells, enabling new tools for genetic engineering and disease modeling.