Circularization of genes and chromosome by CRISPR in human cells
Henrik Devitt Møller, Lin Lin, Xi Xiang, Trine Skov Petersen, Jinrong Huang, Luhan Yang, Eigil Kjeldsen, Uffe Birk Jensen, Xiuqing Zhang, Xin Liu, Xun Xu, Jian Wang, Huanming Yang, George McDonald Church, Lars Bolund, , Yonglun Luo
This study demonstrates CRISPR/Cas9 can generate extrachromosomal circular DNA and ring chromosomes in human cells, enabling new tools for genetic engineering and disease modeling.
Nucleic Acids Research · Aug 22, 2018Peer-reviewedGenomics