Author

Megan J. Riker

University of Iowa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:multiome· 1

Frequent Co-Authors

Budd A. TuckeriD· 3 shared Robert F. MullinsiD· 3 shared Edwin M. StoneiD· 2 shared A. Ajose· 1 shared Allison T. Wright· 1 shared Andrew P. VoigtiD· 1 shared Bradley A. EricksoniD· 1 shared Brynnon E. HarmaniD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersGenetics

Budd A. TuckerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Modeling MEK inhibitor-Associated Retinopathy in vitro using human induced pluripotent stem cell-derived retinal pigment epithelial cells

Lola P. Lozano, Madeleine K. Jennisch, Renato Jensen, Jason A Ratcliff, Luke A. Wiley, Brynnon E. Harman, Megan J. Riker, Allison T. Wright, Bradley A. Erickson, H. Culver Boldt, Timothy M. Boyce, Robert F. Mullins, Elaine M. Binkley, Budd A. Tucker

This study investigates the effects of MEK inhibitor selumetinib on hiPSC-derived RPE cells, finding increased internalization of rod outer segments and decreased aquaporin 1 expression, suggesting a mechanism for MEKAR.

bioRxiv · Oct 3, 2025 · PreprintMolecular Biology

Multimodal single-cell analysis of non-random heteroplasmy distribution in human retinal mitochondrial disease

Nathaniel K. Mullin, Andrew P. Voigt, Miles J. Flamme‐Wiese, Xiuying Liu, Megan J. Riker, Katayoun Varzavand, Edwin M. Stone, Budd A. Tucker, Robert F. Mullins

The paper uses multimodal single-cell sequencing to show non-random distribution of a pathogenic mtDNA variant in retinal cells of a MELAS patient.

JCI Insight · Jun 8, 2023Peer-reviewedGenetics

Genetic modifiers of Cep290-mediated retinal degeneration

Kacie J. Meyer, S. Scott Whitmore, Erin R. Burnight, Megan J. Riker, Hannah E. Mercer, A. Ajose, Gareth R. Howell, Edwin M. Stone, Robert F. Mullins, Budd A. Tucker, Todd E. Scheetz, Michael G. Anderson

The paper identifies genetic modifiers of CEP290-mediated retinal degeneration in mice using QTL analysis and genetic crosses.

bioRxiv · Jan 26, 2022 · PreprintGenetics