Man-Ru Wu

MKMC enables reference-free transcriptomic analysis using k-mer representations, detecting isoform-specific events and matching alignment-based methods in differential expression and age prediction.

This paper reviews mitochondrial transplantation for eye diseases and evaluates delivery methods, finding that different routes target distinct retinal areas and show feasibility for further study.

The paper creates a multi-tissue transcriptomic aging atlas in killifish, identifies age-altered pathways, and develops tissue-specific transcriptomic clocks with sex-specific biomarkers for aging prediction.

This study identifies Muller glial cells as sensitive to diabetes and shows that Zfp36 expression in these cells can protect against diabetic retinopathy.

The paper shows that Mettl14-mediated m6A modification is critical for cell cycle progression of late-born retinal progenitor cells, preventing cell cycle arrest and neuronal death.

The paper introduces iGWAS, a method using self-supervised deep learning to extract phenotypes from medical images for GWAS, finding new genetic loci related to retinal vessel development.