Jingxun Chen

Sexual reproduction impacts vertebrate organ aging

This study shows that lifelong mating in killifish affects liver aging in a sex-specific manner and is associated with younger transcriptomic and proteomic ages in humans.

MKMC enables reference-free transcriptomic analysis using k-mer representations

MKMC enables reference-free transcriptomic analysis using k-mer representations, detecting isoform-specific events and matching alignment-based methods in differential expression and age prediction.

Engulfment by brain macrophages in a short-lived vertebrate

This study identifies brain macrophages in the African turquoise killifish that engulf brain extracellular material, showing age-related decline in engulfment capacity.

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish

The paper creates a multi-tissue transcriptomic aging atlas in killifish, identifies age-altered pathways, and develops tissue-specific transcriptomic clocks with sex-specific biomarkers for aging prediction.

BayesAge 2.0: A Maximum Likelihood Algorithm To Predict Transcriptomic Age

BayesAge 2.0 predicts transcriptomic age from RNA-seq data using a maximum likelihood algorithm with Poisson distribution and LOWESS smoothing, improving accuracy and efficiency over traditional models.

Tunable Transcriptional Interference at the Endogenous Alcohol Dehydrogenase Gene Locus in Drosophila melanogaster

The paper shows that transcriptional interference at the endogenous Adh locus in Drosophila melanogaster is developmentally regulated and tunable through distal promoter activity.

Aurora B-dependent Ndc80 Degradation Regulates Kinetochore Composition in Meiosis

This study shows that Aurora B-dependent phosphorylation of Ndc80 promotes its degradation during meiosis, regulating kinetochore composition and preventing chromosome mis-segregation.