Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against Ebola virus
Jonah M. Elliff, Lindsey Grady, Kyle Lee O’Donnell…·Wendy J. Maury
This study shows that acute malaria infection reduces the effectiveness of a low-dose Ebola vaccine by impairing antibody responses in lymph node macrophages, which can be mitigated with higher vaccine doses.