Author

Kyle Lee O’Donnell

National Institute of Allergy and Infectious DiseasesORCID 0000-0002-7183-1966Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:non-human primate· 3 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Organism:mouse· 1 Assay:proteomics· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Andrea MarziiD· 4 shared Brian J. SmithiD· 2 shared Chad S. ClancyiD· 2 shared Friederike FeldmanniD· 2 shared Heinz FeldmanniD· 2 shared Joseph F. Rhoderick· 2 shared Paige FletcheriD· 2 shared Alejandro A. PezzuloiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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4 shared papersMicrobiology

Andrea MarziORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

A Single-Dose Bundibugyo Virus Vaccine Protects Macaques Within 3 Days

Kyle Lee O’Donnell, Jil Alexandra Haase, Corey W. Henderson, B. Ryder Gathright, Paige Fletcher, Joseph F. Rhoderick, Chad S. Clancy, Shilpi Jain, César G. Albariño, Brian J. Smith, Andrea Marzi

A single-dose VSV-BDBV vaccine protects macaques from BDBV challenge within 3 days by inducing neutralizing antibodies and Fc effector function.

bioRxiv · Jun 15, 2026 · PreprintMicrobiology

Low-dose VSV-EBOV vaccination provides rapid protection from lethal Ebola virus challenge

Andrea Marzi, Wakako Furuyama, Amanda J. Griffin, Friederike Feldmann, Kyle Shifflett, Elizabeth R. Wrobel, Kyle Lee O’Donnell, Patrick W. Hanley, Heinz Feldmann

This study evaluates the protective efficacy of low-dose VSV-EBOV vaccines in nonhuman primates, finding reduced protection with a Makona GP vaccine compared to a Kikwit GP vaccine.

bioRxiv · Feb 15, 2026 · PreprintMicrobiology

Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against Ebola virus

Jonah M. Elliff, Lindsey Grady, Kyle Lee O’Donnell, Caitlin O. Messingham, Kai J. Rogers, Jobaida Akther, Andrew L. Thurman, Rahul Vijay, Alejandro A. Pezzulo, Troy D. Randall, Andrea Marzi, Noah S. Butler, Wendy J. Maury

This study shows that acute malaria infection reduces the effectiveness of a low-dose Ebola vaccine by impairing antibody responses in lymph node macrophages, which can be mitigated with higher vaccine doses.

mBio · Dec 30, 2025Peer-reviewedMicrobiology

Single-dose VSV-Sudan virus vaccine protects from lethal Sudan virus infection within one week: a challenge study in macaques

Paige Fletcher, Kyle Lee O’Donnell, Friederike Feldmann, Joseph F. Rhoderick, Chad S. Clancy, Cecilia A. Prator, Brian J. Smith, Bronwyn M. Gunn, Heinz Feldmann, Andrea Marzi

A single dose of VSV-SUDV vaccine protected macaques from lethal SUDV infection within one week, while VSV-EBOV provided no cross-protection.

bioRxiv · Mar 26, 2025 · PreprintMicrobiology