Courtney F. Jungers

The paper demonstrates that antisense oligonucleotides (ASOs) can upregulate gene expression by stabilizing mRNA through targeting destabilizing elements like PREs, with therapeutic implications for haploinsufficiency disorders.

This study shows that ZCRB1 is essential for U12 splicing, ciliogenesis, and WNT signaling, with loss-of-function effects observed in human cells and zebrafish.

This paper introduces RAPPL, a rapid, simple, and cost-effective method for isolating ribosomes and translational machinery, demonstrating its utility in functional and structural studies across various species and sample types.

The paper identifies U-rich elements in 3' UTRs as drivers of cryptic splicing in MPRA, showing they affect splice site choice and expression levels.

The paper screens 5'UTR mutations in neurodevelopmental disorder genes to identify functional variants impacting translation and protein production, finding some mutations affect known syndromic autism genes in neurons.

This study identifies GSK3β-mediated multisite and sequential phosphorylation of eIF6 as a mechanism to regulate translation and enhance cell survival during serum starvation.