Andrew L. Thurman

Longitudinal analysis reveals myeloid cell contributions to neuroPASC pathogenesis

This study uses longitudinal single-cell RNA sequencing to show that myeloid cells contribute to sustained neuroinflammation in neuroPASC, with microglia playing a central role.

Acute malaria dysregulates specialized lymph node macrophages to suppress vaccine-elicited protection against Ebola virus

This study shows that acute malaria infection reduces the effectiveness of a low-dose Ebola vaccine by impairing antibody responses in lymph node macrophages, which can be mitigated with higher vaccine doses.

IL-13 decreases susceptibility to airway epithelial SARS-CoV-2 infection but increases disease severity in vivo

This study shows IL-13 protects airway epithelial cells from SARS-CoV-2 infection in vitro but worsens disease severity in mice through eicosanoid signaling.

A predominately pulmonary activation of complement in a mouse model of severe COVID-19

This study identifies pulmonary complement activation in a mouse model of severe COVID-19, showing local complement production and its role in lung injury.

Sex and genetic specific effects on behavioral, but not metabolic, responses to a high fat diet in heterogeneous stock rats

This study shows that high fat diet affects metabolic health similarly in male and female HS rats but only males show altered behavioral responses, with genetic factors influencing both outcomes.

Lentiviral vectors transduce lung stem cells without disrupting plasticity

This study shows that lentiviral vector transduction of airway basal cells does not impair their differentiation or function, suggesting potential for long-term gene therapy in lung diseases.

Topography-dependent gene expression and function of common cell archetypes in large and small porcine airways

The paper compares gene expression and function of airway cell types in small and large porcine airways, finding distinct transcriptomes and functional roles.

Performance of a scalable extraction-free RNA-seq method

This study evaluates a bulk RNA-seq method using direct cell lysis without RNA extraction, showing it produces high-quality data comparable to traditional methods with lower costs.

Single-molecule long-read sequencing reveals the chromatin basis of gene expression

The paper introduces MeSMLR-seq to study chromatin accessibility and nucleosome organization at the single-cell level in yeast, revealing correlations between chromatin states and gene transcription.