Author

Sofia S. Origanti

Saint Louis UniversityORCID 0000-0002-6953-0160Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Edwin AntonyiD· 3 shared Vikas KaushikiD· 3 shared Abhinav VayyetiiD· 2 shared Brian B. BothneriD· 2 shared Jaigeeth DeveryshettyiD· 2 shared Poonam RoshaniD· 2 shared Rahul ChaddaiD· 2 shared Reza DastvaniD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

Edwin AntonyORCID

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Author profile →

5 papers

Recent·Most cited

A Phosphorylation Switch Modulates Configurational Codes in the Oncofetal IGF2BP RNA Binding Paralogs

Vikas Kaushik, Vaishnavi Sanjayan, Jenna R. Mattice, Monika Tokmina‐Lukaszewska, Ricarda Törner, Ilan Edelstein, Rahul Chadda, R. P. KASHYAP, Abhinav Vayyeti, Pralambika Roy, Ryan A. Mehl, Richard B. Cooley, Snorri Th. Sigurdsson, Yaakov Levy, Reza Dastvan, , Edwin Antony

This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.

bioRxiv · Aug 19, 2026 · PreprintBiochemistry

Mechanism of RPA phosphocode priming and tuning by Cdk1/Wee1 signaling circuit

Poonam Roshan, Vikas Kaushik, Ayush Mistry, Abhinav Vayyeti, Aidan Antony, Riley Luebbers, Jaigeeth Deveryshetty, Edwin Antony, Sofia S. Origanti

This study identifies a feedback mechanism involving Cdk1/Wee1 signaling that primes and tunes RPA phosphorylation, crucial for cell cycle progression and DNA damage response.

Nature Communications · Dec 9, 2025Peer-reviewedBiochemistry

Wrapping of single-stranded DNA by Replication Protein A and modulation through phosphorylation

Rahul Chadda, Vikas Kaushik, Iram M. Ahmad, Jaigeeth Deveryshetty, Alex S. Holehouse, Snorri Th. Sigurdsson, Gargi Biswas, Yaakov Levy, Brian B. Bothner, Richard B. Cooley, Ryan A. Mehl, Reza Dastvan, Sofia S. Origanti, Edwin Antony

This study uses single-molecule techniques to show that RPA partially wraps ssDNA and that phosphorylation at Ser-384 modulates this wrapping.

Nucleic Acids Research · Jun 25, 2024Peer-reviewedBiochemistry

Modulation of ribosomal subunit associations by eIF6 is critical for mitotic exit and cancer progression.

Poonam Roshan, Aparna Biswas, Stella Anagnos, Riley Luebbers, Kavya Meena Harish, Sinthyia Ahmed, Megan Li, Nicholas V. Nguyen, Gao Zhou, Frank A. Tedeschi, Vivian M. Hathuc, Zhenguo Lin, Zachary Adam Hamilton, Sofia S. Origanti

This study shows that eIF6 modulates ribosomal subunit associations, affecting mitotic exit and cancer progression by altering translation efficiency of mitotic factors.

bioRxiv · Jun 24, 2024 · PreprintMolecular Biology

Regulation of eIF6 through multisite and sequential phosphorylation by GSK3β

Courtney F. Jungers, Jonah M. Elliff, Daniela S. Masson‐Meyers, Christopher J. Phiel, Sofia S. Origanti

This study identifies GSK3β-mediated multisite and sequential phosphorylation of eIF6 as a mechanism to regulate translation and enhance cell survival during serum starvation.

bioRxiv · Jun 20, 2019 · PreprintMolecular Biology